TESTIMONIALS of Avodart users:
Outstanding! It has essentially stopped my male pattern baldness for several years.
Noticed that hair loss slowed dramatically tarted losing my hair in my early 20s. Started taking Rogaine, then Propecia and was able to dramatically slow down hair loss. With Avodart I have been able to maintain my hair after 2-3 months of use
Excellent response, have used for over 3 yrs and all hairloss has stopped – crown area has filled in
I’ve been on Avodart for a little over two years now. It has completely stopped my hair loss and has thickened my existing hair. It took about 6 months to notice results. I’ve maintained ever since. I’m satisfied with the treatment.
I have been using Avodart for about 5 years now. My hair has regrown on the front, and has almost completely regrown on the crown.
I have had excellent results thus far. I have not noticed any initial or subsequent shedding and have noticed significant and ongoing regrowth in all thinning areas (especially along the hairline).
I noticed increased growth in the crown and vertex sections of my scalp, and noticed a lack of shedding overall. The new growth was visible after 6 months, and the shedding subsided after only 2months.
I started losing hair at 19. Propecia stopped working as effective after 2 years of use. I switched to Avodart and started seeing and feeling improvements within months
Avodart has completely stopped and reversed my hair loss.
Hair loss began to decrease after a few months of using Avodart. there was some very modest regrowth of hair at the crown during the first year. since then, any hair loss has been greatly reduced.
For more information on Avodart visit Medical Wellness Center
GLAXOSMITHLKLINE (GSK) – phase III trials of Avodart for hairloss:
Avodart (Dutasteride)
Avodart® (Dutasteride 0.5mg): The first dual-acting 5 alpha-reductase inhibitor for benign prostatic hyperplasia (BPH), approved by the FDA. Avodart® reduces the 2 enzymes responsible for the conversion of testosterone to DHT – which is a primary concern in hair loss. Where Propecia (Finasteride) only blocks one enzyme, by blocking both Avodart’s® result could be better. We can expect to see Avodart® officially on the market as a hair loss medication in 2006, if approved.
No word yet on Avodart® being approved for hair loss by the FDA. Avodart®, manufactured by GlaxoSmithKline (GSK), was approved in February, 2002 by the Food and Drug Administration (FDA), as a supplemental new drug application for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate. Dutasteride was originally assigned the tentative brand (trade) name of “Duogen.” The manufacturer GSK will market this drug, indicated for the treatment of BPH, under the name “Avodart™.” The drug became available in pharmacies in December, 2002. This new medicine for these patients will improve urinary symptoms, reduce risk of acute urinary retention (AUR), also reducing the risk of the need for BPH-related surgery.
Hair Loss Issues
GSK is believed to have entered Phase III trials with Dutasteride for hair loss. Their Supplemental New Drug Application for hair loss is thought to have been submitted to the FDA sometime in 2001. Avodart™ appears to have a much greater and longer inhibition of DHT than Propecia (Finasteride) in the early testing phases. Is it better than Propecia, and are its side effects greater or more serious? These are questions that are unanswered at this time – but time will tell. It’s currently approved in a 0.5 mg softgel form.
Avodart (Dutasteride), a second-generation 5 alpha-reductase inhibitor, is the first and only medicine to inhibit both the type 1 and type 2 enzymes responsible for the conversion of testosterone to DHT (dihydrotestosterone), the primary cause of prostate growth. Dutasteride’s dual inhibition has been found to decrease levels of DHT by 90 percent at two weeks and 93 percent at two years.
By reducing DHT levels, Avodart (dutasteride reduces the size of an enlarged prostate. This reduction in prostate volume was seen as early as one month with reductions continuing through treatment. Shrinking the enlarged prostate is beneficial for relieving urinary obstruction and improving urinary flow. While improving urinary symptoms Dutasteride also reduces the risk of AUR (the sudden complete inability to urinate), and BPH-related surgery, which are two potential long-term serious consequences of BPH. The pivotal phase III study data were published in this month’s edition of the journal Urology.1
“With dutasteride, we now have a medicine that reduces the production of DHT by more than 90 percent, helping to shrink the prostate,” said Claus Roehrborn, MD, a principal trial investigator and professor and chairman of the Department of Urology at the University of Texas Southwestern Medical Center in Dallas , Texas . “By taking dutasteride, patients can improve urinary symptoms and reduce their risk of suffering from acute urinary retention – where you suddenly can’t urinate at all – or needing BPH-related prostate surgery.”
AvolveÒ , Sweden ‘s trade name for Dutasteride, was approved by the Swedish regulatory authority (MPA) on July 24th 2002 . The MPA agreed to act as the Reference Member State for the Mutual Recognition procedure within Europe and GSK plans to market the drug in all major European markets once approvals are finalized during 2003. The European trade name (Avolve) is still to be confirmed.
Dutasteride Results
These Phase II study results below are required for FDA approval. The Phase III trials for hair loss were scheduled to for March of 2003 in the US . Avodart is expected to be on the market for hair loss in 2006 if approved.
Dutastaride Phase 2 Hair Counts
After six month of treatment, the hair counts measured in a 1 inch diameter circle increased by about ~96 hairs with 0.5mg Dutasteride, compared to about ~72 hairs with 5mg Finasteride. The hair counts increased significantly with an increase in dosage with the biggest gain being ~108 hairs with a dose of 2.5mg Dutasteride. So compared to 5mg Finasteride (Proscar), 2.5 mg Avodart grew about 1.5 times as many hairs. This is why there is so much excitement surround Dutasteride. However, there are still unknown questions about increased side effects compared to Finasteride. The Phase III
Response has been good. Have used for 2 years. Overall hair is better now then when I started. Mostly maintaining but also have a little regrowth.First noticed loss of hair around temple region at age 25. Loss continued for several years and started to get thin in the crown area. Around age 30 took Propecia. Took 1+ year to notice improvement but then worked well for a couple of years. Results started to slow so then around age 33 switched to Avodart and results seemed to improve again. Today crown looks good but have moderate loss around temple.
I have been taking medication for hair loss for several years. I started with Propecia/finasteride, but for the last several years I have been taking Avodart. For the approximate 10 years i have been taking Propecia/Avodart my hair loss has substantially reduced. Taking the medication allows me to maintain my current hair.
Gradual loss from age 19 through 21. Then I used Propecia which slowed it down but didn’t stop it. When I started taking Avodart approximately 6 years ago that is what stopped it and has kept it stable. As per my past forms for renewal, the biggest difference I noticed was in the first year or so. I saw thickening in the back crown area and a stop of the thinning in the front. Over the past several years I have had strong maintenance, I don’t see any noticeable loss of hair. This has
stopped since I have been on Avodart.