(adapalene) is the first new topical treatment for acne since Retin A (tretinoin)
was introduced in 1972. Adapalene is a synthetic retinoid analogue
and it functions in a manner similar to that of tretinoin but demonstrates
greater effectiveness and is gentler on the skin. In medical
studies Differin® reduces the number and severity of acne lesions after
12 weeks of therapy. Differin® has demonstrated greater effectiveness
than the highest strength of topic Retin-A gel. Furthermore, patients
on Differin® experience significantly less skin dryness and skin irritation
than those using Retin-A.
is a disorder of the skin's oil glands (sebaceous glands) located at the
base of the hair follicle resulting in plugged pores and outbreaks of varying
degrees of acne lesions commonly referred to as pimples and zits.
Acne lesions occur most commonly on areas that have the highest concentration
of sebaceous glands: face, neck, upper back, chest and shoulders.
When these oil glands become overactive and plug up the primary lesion
of acne, comedones, commonly referred to as a blackheads (open comedones)
or whiteheads (closed comedones) develop. Comedones are non inflammatory
lesions characteristic of Grade I acne. The classic "pimple" develops
as the bacteria (Propionibacterium
acnes) beneath the skin thrive on this oil and produce redness and
pus, Grade II - Grade III. As this infection spreads into the deeper
layers of the skin pustules and cysts can develop, Grade IV.
IS SUSCEPTIBLE TO ACNE? ADULTS & TEENAGERS!
is the most common skin disease affecting over 70 million people worldwide,
over 17 million in the United States. Acne is not just an adolescent condition.
Acne usually begins around puberty due to an increase in hormonal levels
and usually tends to resolve within 10 years, but there is an increasing
number of people, mostly women, wo are being troubled by acne later in
life. Acne affects nearly 85% of all adolescents and teens are troubled
with acne. Nearly 5 million American adults suffer from acne and
women are twice as likely as men to develop adult acne. In women,
an increase in hormones prior to their menstrual cycle tends to make acne
DO I NEED TO TREAT ACNE?
acne is not a serious life threatening condition, if not treated acne can
cause permanent scarring. Grade III and IV Acne with deep pustules
and cysts result in scarring.
QUALIFIES FOR AN ONLINE DIFFERIN® CONSULTATION?
you are 18 years or older, not pregnant or breast feeding, and have been
diagnosed by a physician with acne vulgaris - Grade I, II or III your are
eligible for an online Differin® physician consultation. Differin®
is NOT indicated for Grade IV.
you have Grade IV acne you need to see your physician or dermatologist
DOES DIFFERIN® WORK TO TREAT ACNE?
(adapalene) 0.1% is applied directly to the face or the affected area and
it works deep inside your pores reducing controlling improper skin buildup
and reducing the inflammatory component of acne . Acne forms when
hormones trigger an abnormal accumulation of skin cells and an overproduction
of oil in skin pores. The pores (hair follicle) become clogged, forming
a plug, and enable bacteria to grow and comedones (whiteheads & blackheads)
and papules and pustules and nodules (pimples) develop. It works by controlling
the improper accumulation of skin cells that plug the pores and helping
skin cells shed normally rather than allowing them to accumulate in pores.
Differin® is effective at clearing up pimples, whiteheads and blackheads
by clearing the pores of oil-blocking skin cells.
WHAT ARE THE DIFFERENCE
BETWEEN DIFFERIN® GEL, SOLUTION & CREAM?
comes in a gel, solution and cream formulated specifically for the special
needs of people with acne.
(adapalene gel) Gel 0.1% and 0.3% is a clear, odorless, oil-free and alcohol-free
gel that is specifically designed to meet the needs of most patients.
It's a light gel that feels nice on your skin. It doesn't contain
alcohol which can overly dry your skin and it isn't oily so it won't leave
any greasy residue behind. The 0.3% Gel comes in a 45gm tube or a
convenient 45gm Pump.
(adapalene) Cream 0.1% is an odorless and elegant cream designed specifically
designed for patients with sensitive skin who need the power of Differin®
in a product that their skin can tolerate. This cream absorbs quickly
(adapalene) Solution 0.1% contains alcohol and is harsher on the skin and
more irritating than either the Gel or Cream. This solution is designed
more for younger acne patients with very oils skin and truncal acne and
it causes MORE irritation than the gel. The solution comes in an
Dab-o-matic applicator or single use Pledgets. Due
to the more severe side effects and skin irritation resulting from Differin®
solution over the Gel or Cream, we DO NOT prescribe Differin® in solution
form over the internet!
WHEN & FOR HOW
OFTEN DO I USE DIFFERIN®?
is applied to the skin once a day in the evening before bedtime.
Differin® must be used consistently as there is no instant or immediate
cure for acne.
Wash the affected area with a mild nonsoap cleanser
Pat dry with a soft towel to remove excess water. Never rub harshly.
Apply a pea-size amount of Gel or Cream. Spread a thin film evenly
over the entire face, avoiding the eyes, lips, angles of the nose, and
mucous membranes. Try not to touch the treated areas.
Wash your hands
care and treatment, acne can be controlled and scarring may be prevented.
Use Differin® exactly as prescribed. Applying excessive amounts
or using the formulation more than once a day will not produce better results
and may cause severe redness, peeling and discomfort.
HOW LONG BEFORE I
affect cell accumulation and reduces the inflammatory response within the
pores. During the first 1 - 2 weeks of treatment, your acne
may appear to get worse. Don't despair. This is expected and
just means that the medication is working on pimples that you may not yet
see. Continue using the product. It can take up 8 - 12 weeks before
you start to see improvement and with continued use further improvement
is expected. How long it takes to clear your pimples will depend
on the severity of your acne. Larger pimples or more severe cases
of acne may take longer to clear than milder cases. Use Differin®
consistently even after your acne goes away on areas where outbreaks usually
occur for prevention. If your acne does not start to improve within
12 weeks, check with your own doctor.
DOES DIFFERIN® DIFFER FROM RETIN-A & OTHER RETINOIC ACIDS?
is a formulation of adapalene which is a new synthetic retinoid analogue
that has demonstrated greater effectiveness than the highest strength of
topical Retin- A gel or other retinoid topical products. In addition
Differin® is MUCH GENTLER to your skin than other retinoid products
with significantly less skin dryness and skin irritation. Adapalene
functions in a manner similar to that of retinoid products but with greater
effectiveness and less irritating side effects. Retinoid therapy
has been recognized for more than 20 years to be excellent acne therapy,
but its usage has been limited in many patients due to it's side effects.
Differin® has been shown to be more effective with better tolerance
and less side effects
into hair follicles where it can exert its anti-inflammatory and comedolytic
Gel and Cream are both formulated specifically for the special needs of
patients with acne.
FACTORS PLAY A PREDISPOSING OR EXACERBATING ROLE IN ACNE?
plays a very important role. Acne is a hereditary disease.
Most people with acne know someone in the family that also had it at sometime.
If both parents had severe acne, you too will have significant acne.
If nobody in your family has bad acne, chances are you will not get severe
acne. The acne skin that has overactive sebaceous glands with increased
cellular and oil production is inherited and these are the precise factors
that Differin® work against and controls.
play a role and during adolescence those prone to acne will begin to break
out. Usually the acne outbreaks subside within 10 years but may continue
on into adulthood. Women are especially prone to outbreaks during
the hormonal changes during their menstrual cycle. It is the
male hormone in both males and females that is the cause the sebaceous
oil gland to become overactive and result in acne outbreaks.
During stressful times such as school exams, deadlines etc the male hormone
in both males and females rise resulting in increased acne flare-ups.
The bacterium, Propionibacterium acnes, which grows beneath the skin thrives
on the oil in the sebaceous gland and plays an important role in the changes
of noninflammatory acne to inflammatory acne.
DIET or BAD HABITS CAUSE ACNE OUTBREAKS? MYTH or FACT?
the beginning of time poor diet and a number of bad habits have been blamed
as the leading causes for acne outbreaks. But the truth is that they
have little or nothing to do with it. And while proper nutrition,
exercise and plenty of sleep are great for general health, they do not
have anything to do with preventing or curing acne.
People who don't wash enough get acne.
If your skin is clean it won't break out.
This is not true. Over-washing may actually irritate you skin. The
blackheads are pores clogged with oil and an accumulation of skin
cells within the pore, not dirt. Bacteria that reside under the skin (not
on the surface of the skin) in the pores cause the inflammation of the
hair follicles that contribute to the formation of pimples.
What you eat plays a big part in how your
skin looks. For example, chocolate and greasy, fired "fast foods"
cause your skin to break out or make your complexion worse.
Food is neither the cause nor the cure for acne, yet many acne sufferers
have followed difficult diets for years. For the most part, the food
that you eat has little to do with acne outbreaks. The notion that
chocolate or greasy, fried fast foods lead to greasy skin is incorrect.
The oils you ingest has nothing to do with oil manufactured in your skin
by the sebaceous gland. Although chocolate and greasy foods causing
acne is a myth, it is possible for an individual to have a unique sensitivity
to a certain food. If you believe a particular food causes your acne
to flare up, avoid it for at least 60 days and see if your acne improves.
DIFFERIN® BE USED ALONG WITH OTHER SKIN MEDICATIONS OR PRODUCTS?
should not be used along with other anti-acne products containing Retinoid,
retinoic acid, trinitoin or Vitamin A such as Retin-A, Retinol, Renova.
should not be used with any skin products containing sulfur, resorcinol
or salicylic acid.
should not be used with any abrasive or medicated soaps, astringents, alcohol,
lime, or witch-hazel products, or any products than can be drying or irritating
to the skin.
should not be used with products containing alpha hydroxy, hydroxy or glycolic
acid containing products.
can not be used with any peeling agents, glycolic peels, chemical peels
or laser peels.
should not be used with benzoyl peroxide, Skinoren or Azelex as they may
be drying or irritating.
can be used with topical anti-acne antibiotic treatments such as erythromycin,
clindamycin, Dalacin-T or Cleocin-T if applied in the morning and Differin®
is applied in the evening before bedtime. The two can not be applied
at the same time. Always check with your prescribing doctor before
can be used with non-oily noncomedogenic moisturizers and cosmetics
KIND OF CLEANSER SHOULD I USE WHILE USING DIFFERIN®?
is not caused by dirt, and too much vigorous washing can dry your skin
or even aggravate your acne. Cleansing twice a day is sufficient
with a mild, NONSOAP, fragrance-free cleanser such as Cetaphil® Cleansing
Bars or Cetaphil® Gentle Skin Cleansers. Do not use medicated
soaps and cleansers that have a strong drying affect.
I WEAR MAKEUP WHILE USING DIFFERIN®?
you can wear makeup. Do NOT use oil-based makeup or cosmetics that
have an abrasive, drying or peeling action. Make sure than when you
buy cosmetics, moisturizers or any other skin products they are labeled
as "noncomedogenic" or "nonacnegenic." This means that they are not
likely to cause whiteheads or blackheads.
USING DIFFERIN® SHOULD I USE A MOISTURIZER ?
acne medication including Differin® can be drying, it may be helpful
to use a moisturizer. Use a mild, fragrance-free, non-oily, non-irritating
moisturizer that is noncomedogenic. Make sure your moisturizer does
NOT contain alpha hydroxy or glycolic acids, retinoid, retinol, vitamin
A, trinitoin, or any other drying or irritating agent. Cetaphil®
Moisturizers are a possible choice.
WHILE TAKING Differin®
CAN I USE TANNING BEDS OR SUNBATHE?
using Differin®, you must avoid all sun exposure possible because Differin®
makes your skin more sensitive to sunlight. Do NOT sunbathe. Do NOT
use tanning beds or sunlamps. When using Differin® you must ALWAYS
take proper precautions to protect sun exposed skin using sunblock, hats
and protective clothing. Never apply Differin® to sunburned skin!
ARE THE SIDE EFFECTS of Differin®?
is gentle on the skin, but 10 -40% of patients do experience some skin
irritation which is reversible when the treatment is discontinued or reduced
in frequency. The most common side effects are erythema (redness),
drying, scaling, irritation, pruritis (itching), burning, stinging and
acne flare-up. Most of these reactions are not severe and occur during
the first month of treatment and resolve with continued use. About
20% of patients experience a feeling of stinging, pruritis or burning
immediately after application. During the initial weeks of therapy if these
adverse effects are too bothersome, you may try decreasing the frequency
of use and as your tolerance improves increase frequency to recommended
once a day usage.
irritation occurs, blistering, crusting or swelling discontinue use and
check with your physician.
SHOULD NOT USE DIFFERIN®?
WHAT ARE THE CONTRAINDICATIONS
Do NOT use
Differin® if you are pregnant or attempting to become pregnant.
Differin® MAY HARM unborn baby.
Do NOT use
Differin® if you are breast feeding.
Do NOT use
Differin® if you are allergic or have hypersensitivity to Adapalene
or any of the components in the Differin® Gel: carbomer 980,
propylene glycol, poloxamer, disodium edetate, methyl hydroxybenzoate,
phenoxyethanol, sodium hydroxide and purified water. Differin® Cream
contains carbomer 934P, cyclomethicone, edetate disodium, glycerin, methyl
glucose sesquistearate, methylparaben, PEG-20 methyl glucose sesquistearate,
phenoxyethanol, propylparaben, purified water, squalane, and trolamine
Do NOT use
Differin® on broken skin, cuts, abrasions, or sunburned skin.
Do NOT use
Differin® if you suffer from eczema, seborrhoeic dermatitis or psoriasis.
Do NOT use
Differin® with any skin products containing sulfur, resorcinol or salicylic
is NOT to be used in children or anyone under the age of 18. Not
approved for pediatric use below age 12 but we do not prescribe for anyone
less than 18 year of age online.
will not prescribe DIFFERIN®
to anyone under the age of 18. Also DIFFERIN®
be used by pregnant women, women attempting to become pregnant or women
who are breast feeding.