CONTRAINDICATIONS:
-
Anyone with any liver function abnormalities,
liver disease, hepatitis or any other medical disorder of liver function
including but not limited to cirrhosis of the liver, liver cancer, jaundice
etc. should not take Avodart. If you have any questions about your medical
condition, consult your primary care physician before taking Avodart.
-
Do NOT use Topical Dutasteride if you
are taking potent Protease Inhibitors: Agenerase (amprenavir), Crixivan
(indinavir), Viracept (nelfinavir), Norvir (ritonavir) or Invirase or Fortovase
(saquinavir).**
-
Do NOT use Topical Dutasteride if you
are taking oral Avodart (dutasteride) or oral Propecia or Proscar (finasteride)
or using topical finasteride or oral ketoconazole (Nizoral) or Sporanox
(Itraconazole).**
-
Do NOT use Topical Dutasteride if you
are allergic to Propecia, Proscar or Finasteride or Avodart or dutasteride
-
Absolutely no one under the age of 18
should take Avodart.
-
Absolutely no female should take Avodart
under any circumstances.
-
Do NOT combine Topical Dutasteride with
Topical or Oral Avodart with Propecia or Proscar (finasteride)
**Dutasteride
is metabolized by human cytochrome P45 isoenzyme CYP3A4. There are
no clinical studies to evaluate the impact of CYP3A4 enzyme inhibitors
on dutasteride pharmacokinetics. However, based on in vitro data
blood concentrations of dutasteride may increase in the presence of POTENT
inhibitors of CYP3A4 such as potent protease inhibitors, ketoconazole,
itraconazole... Therefore there is a potential for drug-drug interaction
of dutasteride and systemic chronic dosing with potent CYP3A4 inhibitors.
In otherwise healthy individuals with no liver disease, topical applications
would not indicate as much caution and would not be a contraindication
to dutasteride, only systemic ORAL ketoconazole or other CYP3A4 inhibitors
would be a contraindication.
IMPORTANT
WARNING:
Pregnant or potentially pregnant woman
should not touch or come in contact with topical Dutasteride or Avodart
capsules and should definitely NOT touch broken or crushed capsules. If
pregnant with a male baby and the pregnant woman is exposed to the active
ingredient in Avodart, the male baby could be born with abnormalities of
the male sex organs.
Men using Topical Dutasteride or
oral Avodart should NOT donate blood for at least 6 months after last dose
to prevent transmission of dutasteride to a pregnant woman via blood transfusion
DUTASTERIDE
SIDE EFFECTS:
The majority of Men using oral Avodart
experience no side effects. Side effects are similar to Propecia side effects
and are usually mild to moderate and tend to go away during treatment course:
Impotence (4.7%), decreased libido (3%), breast tenderness and breast enlargement
(0.5%) and ejaculation disorders (1.4%). The incidence of most drug-related
adverse events decreased with duration of treatment. Topical
Dutasteride decreases possible incidence of any of these side effects
Rarely allergic reactions - seek
immediate emergency medical attention
IMPORTANT
INFORMATION:
Dutasteride can
affect the blood test for the screening of Prostrate Cancer, the PSA (Prostate-Specific
Antigen). It is very important that if you have a PSA test done, you need
to tell your doctor that you are using Topical Dutasteride. Dutasteride
has no effects on prostate cancer nor is it associated with cancer, it
just can affect the reading of the test results. Therefore, in order to
have an accurate screening test, the doctor must be aware that you are
taking Avodart. After 6 months of using Avodart one's PSA levels can be
decreased by as much as 50% and it important to double the value when testing
PSA for prostate cancer detection or following PSA levels for monitoring.
Topical Dutasteride may also affect PSA tests, but probably to a lesser
extent.
DUTASTERIDE
PRESCRIBING INFORMATION:
Oral Avodart has only been approved
by the FDA for the treatment of prostatic enlargement and although it has
been tested and shown to be more effective than Propecia for hair loss
it has not yet been approved as a treatment for hair loss. Medical Wellness
Center has been prescribing oral Avodart since 2002. Dutasteride
is a more potent 5-alpha reductase enzyme inhibitor than Propecia and decreases
serum DHT levels responsible for Male Pattern Hairloss. Therefore Medical
Wellness Center is off-label prescribing oral Avodart and Topical Dutasteride
for Male Pattern Hair Loss Only. We do NOT prescribe Avodart for BPH (prostatic
enlargement) as this condition needs close physician monitoring to prevent
or detect the progression to Prostate cancer. Topical Dutasteride or oral
Avodart prescribed for Male Pattern Hair Loss is NOT covered by insurance. |
